After studying the 16 games on the Week 16 schedule in the NFL, our best bet suggestion is Lions -6.5. For more tips, which could lead to parlay opportunities, scroll down.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 16 Spread Bets

Jump to Matchup:

JAX-LV | SF-MIA | DEN-LAC | HOU-KC | MIN-SEA

Pick: Raiders -1 vs. Jaguars

• Matchup: Jacksonville Jaguars at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 1.1 points (Bet on this game at BetMGM)
• Spread: Raiders -1
• Time: 4:25 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: 49ers +1 vs. Dolphins

• Matchup: San Francisco 49ers at Miami Dolphins
• Projected Winner & Margin: 49ers by 1.5 points (Bet on this game at BetMGM)
• Spread: Dolphins -1
• Time: 4:25 p.m. ET
• Date: Dec. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +2.5 vs. Chargers

• Matchup: Denver Broncos at Los Angeles Chargers
• Projected Winner & Margin: Broncos by 0.7 points (Bet on this game at BetMGM)
• Spread: Chargers -2.5
• Time: 8:15 p.m. ET
• Date: Dec. 19
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Chiefs -3 vs. Texans

• Matchup: Houston Texans at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 7.2 points (Bet on this game at BetMGM)
• Spread: Chiefs -3
• Time: 1 p.m. ET
• Date: Dec. 21
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings -3 vs. Seahawks

• Matchup: Minnesota Vikings at Seattle Seahawks
• Projected Winner & Margin: Vikings by 4.6 points (Bet on this game at BetMGM)
• Spread: Vikings -3
• Time: 4:05 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 16 Total Bets

Jump to Matchup:

Over 45.5 – Eagles vs. Commanders

• Matchup: Philadelphia Eagles at Washington Commanders
• Projected Total: 47.4 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 42.5 – Vikings vs. Seahawks

• Matchup: Minnesota Vikings at Seattle Seahawks
• Projected Total: 44.6 points (Bet on this game at BetMGM)
• Time: 4:05 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 45 – Steelers vs. Ravens

• Matchup: Pittsburgh Steelers at Baltimore Ravens
• Projected Total: 48.3 points (Bet on this game at BetMGM)
• Time: 4:30 p.m. ET
• Date: Dec. 21
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41.5 – Texans vs. Chiefs

• Matchup: Houston Texans at Kansas City Chiefs
• Projected Total: 43.4 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Dec. 21
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 48 – Lions vs. Bears

• Matchup: Detroit Lions at Chicago Bears
• Projected Total: 47.0 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Dec. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.