With eight games on the CUSA Week 4 college football slate, there are plenty of options to consider before placing any bets. Our model thinks Jacksonville State (-6) against Southern Miss is the best bet on the spread, while the East Carolina vs. Liberty matchup is the best over/under to bet on. Get even more insights and stats on those and other games to bet on or include in a parlay in the article below.

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Best Week 4 CUSA Spread Bets

Pick: Jacksonville State -6 vs. Southern Miss

• Matchup: Southern Miss Golden Eagles at Jacksonville State Gamecocks
• Projected Winner & Margin of Victory: Jacksonville State by 14.4 points
• Date/Time: Sept. 21 at 3:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Pick: Middle Tennessee +14.5 vs. Duke

• Matchup: Duke Blue Devils at Middle Tennessee Blue Raiders
• Projected Winner & Margin of Victory: Duke by 7.1 points
• Date/Time: Sept. 21 at 4:00 PM ET
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: UTEP +9.5 vs. Colorado State

• Matchup: UTEP Miners at Colorado State Rams
• Projected Winner & Margin of Victory: Colorado State by 5.8 points
• Date/Time: Sept. 21 at 5:00 PM ET
• TV Channel: truTV
• Live Stream: Watch on Max

Pick: Western Kentucky +2.5 vs. Toledo

• Matchup: Toledo Rockets at Western Kentucky Hilltoppers
• Projected Winner & Margin of Victory: Toledo by 1.4 points
• Date/Time: Sept. 21 at 7:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Pick: New Mexico State +16.5 vs. Sam Houston

• Matchup: New Mexico State Aggies at Sam Houston Bearkats
• Projected Winner & Margin of Victory: Sam Houston by 15.5 points
• Date/Time: Sept. 21 at 7:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Use these spread picks at BetMGM today!

Best Week 4 CUSA Total Bets

Under 54.5 – East Carolina vs. Liberty

• Matchup: East Carolina Pirates at Liberty Flames
• Projected Total: 41.5 points
• Date/Time: Sept. 21 at 6:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Under 50.5 – UTEP vs. Colorado State

• Matchup: UTEP Miners at Colorado State Rams
• Projected Total: 43.5 points
• Date/Time: Sept. 21 at 5:00 PM ET
• TV Channel: truTV
• Live Stream: Watch on Max

Over 44.5 – New Mexico State vs. Sam Houston

• Matchup: New Mexico State Aggies at Sam Houston Bearkats
• Projected Total: 50.7 points
• Date/Time: Sept. 21 at 7:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Under 57.5 – Tulsa vs. Louisiana Tech

• Matchup: Tulsa Golden Hurricane at Louisiana Tech Bulldogs
• Projected Total: 51.8 points
• Date/Time: Sept. 21 at 7:00 PM ET
• TV Channel: ESPN+
• Live Stream: Watch this game on ESPN+

Over 51.5 – Duke vs. Middle Tennessee

• Matchup: Duke Blue Devils at Middle Tennessee Blue Raiders
• Projected Total: 54.5 points
• Date/Time: Sept. 21 at 4:00 PM ET
• TV Channel: ESPNU
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Take advantage of our picks and place your bet at BetMGM today!

Week 4 CUSA Standings

Watch CUSA games all season long on Fubo and ESPN+!

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