Based on our projections, the best bet against the spread in the NFL among Week 3’s 16 games is Colts -1 — for more suggestions, including parlay opportunities, scroll down.

NFL Picks Against the Spread – Week 3

Jump to Matchup:

Pick: Colts -1 vs. Bears

• Matchup: Chicago Bears at Indianapolis Colts
• Projected Winner & Margin: Colts by 2.8 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +1.5 vs. Ravens

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Winner & Margin: Ravens by 0.7 points (Bet on this game at BetMGM)
• Spread: Ravens -1.5
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers +2 vs. Steelers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 1.9 points (Bet on this game at BetMGM)
• Spread: Steelers -2
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Vikings +2.5 vs. Texans

• Matchup: Houston Texans at Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.1 points (Bet on this game at BetMGM)
• Spread: Texans -2.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints -3 vs. Eagles

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Winner & Margin: Saints by 23.3 points (Bet on this game at BetMGM)
• Spread: Saints -3
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers +3 vs. Titans

• Matchup: Green Bay Packers at Tennessee Titans
• Projected Winner & Margin: Packers by 9.0 points (Bet on this game at BetMGM)
• Spread: Titans -3
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Cardinals +3 vs. Lions

• Matchup: Detroit Lions at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 10.2 points (Bet on this game at BetMGM)
• Spread: Lions -3
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs -3.5 vs. Falcons

• Matchup: Kansas City Chiefs at Atlanta Falcons
• Projected Winner & Margin: Chiefs by 5.8 points (Bet on this game at BetMGM)
• Spread: Chiefs -3.5
• Time: 8:20 PM ET
• Date: Sept. 22
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks -4.5 vs. Dolphins

• Matchup: Miami Dolphins at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 17.3 points (Bet on this game at BetMGM)
• Spread: Seahawks -4.5
• Time: 4:05 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Raiders -5.5 vs. Panthers

• Matchup: Carolina Panthers at Las Vegas Raiders
• Projected Winner & Margin: Raiders by 16.7 points (Bet on this game at BetMGM)
• Spread: Raiders -5.5
• Time: 4:05 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bills -5.5 vs. Jaguars

• Matchup: Jacksonville Jaguars at Buffalo Bills
• Projected Winner & Margin: Bills by 22.9 points (Bet on this game at BetMGM)
• Spread: Bills -5.5
• Time: 7:30 PM ET
• Date: Sept. 23
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Patriots +6.5 vs. Jets

• Matchup: New England Patriots at New York Jets
• Projected Winner & Margin: Patriots by 11.8 points (Bet on this game at BetMGM)
• Spread: Jets -6.5
• Time: 8:15 PM ET
• Date: Sept. 19
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Browns -6.5 vs. Giants

• Matchup: New York Giants at Cleveland Browns
• Projected Winner & Margin: Browns by 17.4 points (Bet on this game at BetMGM)
• Spread: Browns -6.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Broncos +7 vs. Buccaneers

• Matchup: Denver Broncos at Tampa Bay Buccaneers
• Projected Winner & Margin: Broncos by 6.0 points (Bet on this game at BetMGM)
• Spread: Buccaneers -7
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +7.5 vs. 49ers

• Matchup: San Francisco 49ers at Los Angeles Rams
• Projected Winner & Margin: 49ers by 3.7 points (Bet on this game at BetMGM)
• Spread: 49ers -7.5
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Bengals -7.5 vs. Commanders

• Matchup: Washington Commanders at Cincinnati Bengals
• Projected Winner & Margin: Bengals by 25.2 points (Bet on this game at BetMGM)
• Spread: Bengals -7.5
• Time: 8:15 PM ET
• Date: Sept. 23
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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